delivered the opinion of the court as modified upon rehearing:
Plaintiffs Meyer Proctor and Marjorie Proctor (sometimes collectively Proctor) filed this medical malpractice and products liability action against Dr. Michael J. Davis (Dr. Davis) and the Upjohn Company (Upjohn), alleging serious injury resulting from Dr. Davis’ injection of the corticosteroid Depo-Medrol, manufactured by Upjohn, directly into Meyer Proctor’s left eye on November 7, 1983. A jury exonerated Dr. Davis, but found against Upjohn, awarding Proctor compensatory damages of $3,047,819.76, and punitive damages of $124,573,750, the latter of which the circuit court remitted to $35 million. Proctor and Upjohn appealed from that judgment. Proctor also cross-appealed the denial of their motion for sanctions and attorney fees.
On June 28, 1994, a unanimous opinion was filed by this court affirming the jury’s decision as to Dr. Davis and its award as to Upjohn, but reducing the punitive damages to $3,047,819.76. Upjohn’s motion for rehearing was allowed and further oral argument ensued. The June 28, 1994, opinion was withdrawn. Two members of this court issued another opinion, affirming the verdict as to Dr. Davis, but reversing outright the jury’s award as to Upjohn (Proctor v. Davis, 275 Ill. App. 3d 593, 656 N.E.2d 23 (1995)), with a lengthy dissent. Proctor, 275 Ill. App. 3d at 613-27 (Hartman, J., concurring in part and dissenting in part). Our supreme court invalidated that opinion because one of the majority judges, Justice McCormick, had retired before the opinion was to become effective. This court was directed "to enter a constitutionally valid opinion or order disposing of the matters raised, briefed and argued subsequent to Upjohn’s unanimously allowed rehearing petition.” Proctor v. Upjohn Co., 175 Ill. 2d 394, 397, 677 N.E.2d 918 (1997). Our opinion and companion Supreme Court Rule 23 order follow.
Upjohn’s claims regarding its duty to warn and punitive damages will be considered, in part, in this opinion. All remaining issues and contentions will be determined in a separate Supreme Court Rule 23 order disseminated contemporaneously with this opinion.
In 1959, the Food and Drug Administration (FDA) approved Upjohn’s "New Drug Application” (NDA) for Depo-Medrol, a sterile, aqueous suspension containing methyl prednisone acetate, a corticosteroid, for treatment of various inflammatory bodily disorders. The FDA’s approval was limited to intramuscular (in the muscle), intraarticular (in the joint), and intralesional (in a lesion) injections. According to the evidence, Depo-Medrol is an insoluble, toxic material, which is intended to be released in the body over a period of six to *269eight weeks in human tissue with adequate blood supply; however, the human eye does not possess such a blood supply. Depositing Depo-Medrol into the eye meant that the drug would remain in the eye for a relatively long time. Because of its insolubility, its crystals had an effect on the body’s response to it when inserted, including increased intraocular pressure and other trauma. It became a foreign body in the eye, which was very difficult, if not impossible, to remove once injected into the eye.
Shortly after Depo-Medrol’s FDA limited approval, two ophthalmologists contacted Upjohn independently, each wishing to use the drug clinically for the treatment of ophthalmic conditions through an unapproved method of administration—periocular (near the eye) injections.1 This use of Depo-Medrol was neither approved by the FDA nor listed on Depo-Medrol’s label (off-label use). Nevertheless, Upjohn immediately provided both with vials of Depo-Medrol without cautioning them that no animal studies had been initiated to test the reaction of the drug upon living tissue before embarking upon human use. Instead, Dr. Porter Crawford, an Upjohn employee responsible for monitoring Depo-Medrol at the time, encouraged this unapproved off-label use, as follows:
"Thank you very much for *** your interest in Depo-Medrol for subconjunctival injection in the treatment of uveitis. We do not have any reports concerning this use for the preparation and we would very much like for you to evaluate it in this way.” (Emphasis added.)
Dr. Crawford sent vials of Depo-Medrol to the inquiring doctor and asked him to let him know when he needed additional supplies. Dr. Crawford also noted that Upjohn would "be anxious to learn how it performs when used this way.”
Upjohn dispensed not only vials of Depo-Medrol but, also, financial assistance to doctors who would use Depo-Medrol for the unapproved off-label use of periocular injections, granting one in 1959, $3,000. This doctor later wrote Upjohn that he had given two talks in Chicago in the fall of 1960, extolling the use of Depo-Medrol *270for subconjunctival injections, although he knew otherwise, having written in the same letter that the "experimental work *** fell flat since we are unable to find anything in the aqueous.” (Emphasis added.) In response, Upjohn wrote back that the FDA "has not approved this use of Depo-Medrol because we have had no clinical work to show to them.” Upjohn asked the doctor to prepare a write-up of his cases or publish an article in order to document this off-label use for possible FDA approval. Upjohn noted that "not too many people are actually using this type of therapy and your good results suggest that the work should be scattered about.”
Upjohn itself undertook the task of "scattering about” the unapproved off-label use of Depo-Medrol to the medical community. In 1961, an article on the use of Depo-Medrol was written by the experimenting doctor to whom Upjohn had given $3,000. This doctor informed Dr. Crawford, on August 31, 1961, of the completion of the article, noting separately, however, that he was unable to use any of his animal experiments because the results were "very unsatisfactory.” (Emphasis added.) Proctor’s expert, Dr. Philip Walson, who reviewed this correspondence, believed the omission of the animal studies created a serious problem because collected data was ignored, and the animal studies, although "unsatisfactory,” should have been included in the article touting this use of Depo-Medrol.
Upjohn nevertheless ordered and distributed 2,500 reprints of the article, 500 for "hospital sales” and 2,000 for "sales education,” thus becoming part of the "literature” to which the ophthalmic community was exposed.2 On November 16, 1961, Upjohn requested reprints of another experimenting doctor’s article for distribution, which also mentioned the use of subconjunctival injections of Depo-Medrol.3 More "fodder” priming the sales pump.
On March 8, 1963, Upjohn’s Dr. Samuel Stubbs wrote to a differ*271ent experimenting doctor, requesting case histories on the patients he had treated with Depo-Medrol, which Upjohn would use to supplement its original NDA. Dr. Stubbs informed him that Upjohn would compensate him for his time, and that of his secretary, in preparing the case reports. In response, by letter dated March 14, 1963, the doctor stated that he would begin working on the case reports and requested that Upjohn meanwhile send him more Depo-Medrol, which, on March 19, 1963, Upjohn did without mentioning the information and precautions suggested by its Dr. Gerard to its salesmen in 1962. E.g., 291 Ill. App. 3d at 270-71 n.3.
Harry P. Davis, Jr., an Upjohn sales representative, wrote to Mr. Crissman at Upjohn on June 12, 1963, informing him that two Ohio physicians were using Depo-Medrol for "severe, chronic or acute, uveitis by retrobulbar injection,” but that neither physician was aware that anything had been published on the use of this drug. Dr. Stubbs wrote to these two Ohio doctors on June 26, 1963, informing them of Upjohn’s interest and asking for case reports of their experience with the drug. Further, if they were interested in publishing their work, Dr. Stubbs would make the "services of The Upjohn Writing Staff” available to them, would pay for their secretary’s time, and would compensate the doctors for work on the case reports, admittedly intending to "plant the seed” in those doctors’ minds about publishing an article.
On July 1, 1963, the Ohio doctors responded with eight case reports, which Dr. Stubbs referred to Harold Tucker, one of Upjohn’s medical writers, for potential publication.4 An article written as a result of Upjohn’s "expert assistance” proclaimed that positive *272results from the subconjunctival injection of Depo-Medrol had been confirmed by others5 All the while, Upjohn’s own expert, Dr. Stubbs, himself questioned the validity of the so-called studies. On September 19, 1963, he wrote to Jack Toole, Upjohn’s hospital representative, criticizing the data, stating:
"I’m enclosing a copy of the letter I have written to him, and it is a mild rebuff for the lousy data he sent us. This sort of thing may have gone through before the new [FDA] regulations, but it certainly doesn’t go now, and at the risk of not getting any more data at all I feel it’s time to start setting down on some of these rather loose individuales [szc], I think [this doctor] is a good friend of ours and I don’t have to [sic] many qualms that he is going to be upset, but really the stuff that he let you send to me is almost worthless for reasons as I mentioned in the letter to him.” (Emphasis added.)6
Dr. Stubbs nevertheless forwarded more vials of Depo-Medrol to this doctor, followed by another supply of Depo-Medrol, on January 21, 1964.
The practice of publicizing unapproved uses of drugs, when *273sponsored by the pharmaceutical company, is not approved by the FDA as proper advertising; it results in continuing, unapproved, potentially dangerous use. Dr. Stubbs was aware that those experimenting physicians would subsequently write publications that appeared in medical journals,7 for which Upjohn paid secretarial and editorial expenses. These writings, of course, would be addressed to the medical community and become available to ophthalmologists, thereby becoming, incredibly, part of the current medical literature attempting to establish the standard of medical expertise.
In 1965, Dr. Stubbs collected articles in the medical literature and prepared a report for internal use by Upjohn.8 Based on that report, he and his immediate supervisor recommended that Upjohn consider filing a supplemental NDA to obtain FDA approval for periocular administration of the drug. Without FDA approval, Upjohn could not include that use of Depo-Medrol as an approved method of administration on the drug’s labeling. In order to supple*274ment the NDA to provide for periocular administration of Depo-Medrol, Upjohn knew that it was "likely that animal tissue tolerance studies” would have to be performed.
Upjohn elected not to pursue a supplemental NDA for periocular administration. A corporate memorandum recommended that "no further Medical Development work be done with Depo-Medrol administered by [periocular] injection,” and that "tissue tolerance studies in animals not be undertaken by Biomedical Research unless a request for [an NDA] supplement is initiated by Marketing, and approved in accordance with the currently effective Pharmaceutical New Product System procedures.”
Upjohn stipulated that prior to November 7, 1983, it "had the capacity to perform in-house or refer out-of-house [experiments] to be done by private consultants’ research in the form of animal studies and all four phases of human studies.” Upjohn had in its employ, or available to it, physicians, toxicologists, pharmacologists, statisticians and epidemiologists. Dr. Stubbs admitted that the animal tissue tolerance studies could have been performed if the company had wanted to do them and had the funding to do so. Such studies were already ongoing with other applications of the drug. If Upjohn had begun the animal tissue tolerance studies on the periocular use of Depo-Medrol in 1969 or 1970, it would have had the results well in advance of the casualty involved in this and, perhaps, other cases. Dr. Stubbs acknowledged that the decision whether to go forward with animal studies and supplements on Depo-Medrol for subconjunctival use was left to Upjohn’s marketing staff. Dr. Walson believed that marketing should not have been allowed to decide a medical safety and scientific issue.
Upjohn knew of potential adverse reactions to the drug, of which it learned over a period of preceding years from drug experience reports (DERs),9 yet its labeling never referred to unapproved periocular injection of the drug, neither listing it as an appropriate *275method of administration, including any recommended dosages, nor stating any warnings regarding periocular use. Ophthalmologists, not having been advised of adverse reactions, began making extensive use of periocular injections of Depo-Medrol because the benefits seemingly outweighed the risks. Defendant Dr. Davis, himself, and four others testified to routine periocular administration of the drug.
In October 1980, in response to the FDA’s global restructuring of labeling for all corticosteroids, Upjohn proposed a revised Depo-Medrol package insert. The proposed insert included the following statement:
"ADVERSE REACTIONS REPORTED WITH NONRECOMMENDED ROUTES OF ADMINISTRATION ***
Ophthalmic: (Subconjunctival)—Redness and itching, obtuse, slough at injection site, increased intraocular pressure, decreased vision. (Retrobulbar)—Blindness.”
In September 1983, the FDA informed Upjohn that it should not make its proposed changes but, rather, should "continue using currently approved labeling” until it received "notification” from the agency. The FDA also told Upjohn that "[i]f important new labeling information becomes available, you should revise your approved product labeling under 21 C.F.R. 314.8.” The circuit court excluded this evidence.10
In April 1983, Meyer Proctor, a retired public relations worker, consulted Dr. Davis with complaints of blurred vision. Dr. Davis diagnosed Proctor’s condition as uveitis, an inflammation of the eye, which can be chronic and can lead to permanent blindness. Dr. Davis began treating this condition with steroid medications applied to both of Proctor’s eyes by means of eye drops, which proved to be of only limited value. In May 1983, Proctor developed cystoid macular edema (CME) as a complication of the uveitis, and the vision in his left eye deteriorated to the level of legal blindness. Dr. Davis referred him to a retinal-vitreal specialist for further evaluation and treatment, who concurred in the diagnosis of CME and prescribed Nalfon, a nonsteroidal anti-inflammatory medication. Some improvement in Proctor’s vision occurred, but his sight was not restored to normal. After treating Proctor for several months, the specialist referred him back to Dr. Davis, recommending the use of a nonsteroidal anti-inflammatory drug (such as Nalfon), or the systemic or periocular administration of a steroid (such as Depo-Medrol) if continued impairment of vision made further treatment necessary.
*276On August 1, 1983, Dr. Davis examined Proctor and reinstituted treatment with Nalfon; however, his vision again began to deteriorate. On August 9, 1983, Dr. Davis decided to use periocular injections of Depo-Medrol to treat Proctor’s condition, one shot around each eye. Within several weeks, Proctor’s vision improved almost to normal, but in November 1983, Proctor experienced renewed problems with the vision in his left eye. In response, on November 7, 1983, Dr. Davis administered another periocular injection of Depo-Medrol near that eye.
All the ophthalmologists who testified at trial regarding the standard of care concluded that Dr. Davis’ decision to administer Depo-Medrol via periocular injection both in August and again in November of 1983 was appropriate and within the applicable standard of care. None suggested that anything known at the time, or subsequently discovered, would have made this treatment inappropriate. There were risks associated with this treatment, however. Dr. Davis himself testified that in November 1983 he knew that an inadvertent intraocular injection was a risk of any periocular injection; Depo-Medrol could be "toxic” if inadvertently injected into the eye and cause damage to the eye, including blindness; he had never penetrated the globe of the eye (made an intraocular injection) in more than 1,600 prior periocular injections of Depo-Medrol in his entire career; and he believed he would be able to deliver the drug to its intended location without incident in this instance.
During the November 7, 1983, injection, however, Dr. Davis mistakenly inserted the needle and Depo-Medrol into Proctor’s left eye. Dr. Davis then referred Proctor to a specialist for evaluation and treatment, who determined that the appropriate treatment was observation, waiting for the drug to clear from the eye, and watching for possible retinal detachment, which eventually occurred. Proctor underwent surgery on November 23, 1983, the Depo-Medrol was removed from Proctor’s left eye, and the retina was reattached. The retina again detached, however, and two subsequent operations, on December 13 and 29, 1983, failed to reattach it. In April 1984, Proctor’s left eye, having become blind and painful, was surgically removed.
Proctor filed suit on February 14, 1984, against Dr. Davis and Upjohn. Discovery proceeded over a period of seven years, and trial began on September 4, 1991.
Proctor alleged that Dr. Davis violated the standard of care in one or more ways, directly and proximately causing the injury. Also alleged was negligence based on res ipso loquitur and loss of consortium. Proctor’s allegations against Upjohn were based on strict *277product liability, claiming that Depo-Medrol was defective, unsafe, and unreasonably dangerous, and that Upjohn’s failure to warn Dr. Davis about the potential harm resulting from an intraocular injection directly and proximately caused the injury. Also alleged was loss of consortium and willful, wanton, or reckless acts or omissions that would support punitive damages.
On October 18, 1991, the jury returned verdicts in favor of Dr. Davis and against Upjohn. The jury awarded Meyer Proctor $3,047,819.76 in compensatory damages and $124,573,750 in punitive damages, and Marjorie Proctor $100,000 in compensatory damages. On September 3, 1992, the circuit court entered an order remitting the punitive damages to $35 million, but otherwise leaving the verdict intact. Proctor filed a notice of appeal as to the Dr. Davis verdict; Upjohn then filed its notice of appeal; and Proctor filed a notice of cross-appeal against Upjohn.
I
Upjohn first argues that, after considering all the evidence in the case in the light most favorable to Proctor, it was entitled to either judgment notwithstanding the verdict or a new trial because Proctor failed to prove that a warning was required, because the risk was too remote to require a warning, and because the specialized medical community was already aware of the risks. The standards for judgment notwithstanding the verdict (see Pedrick v. Peoria & Eastern R.R. Co., 37 Ill. 2d 494, 229 N.E.2d 504 (1967) (Pedrick)) and for a new trial (see Maple v. Gustafson, 151 Ill. 2d 445, 603 N.E.2d 508 (1992) (Maple)) differ; Upjohn’s contentions will be considered under both standards.
In Illinois, there is no duty to warn of a risk that is already known by those to be warned. Kokoyachuk v. Aeroquip Corp., 172 Ill. App. 3d 432, 526 N.E.2d 607 (1988). A duty to warn exists only when there is "unequal knowledge and the defendant, possessed of such knowledge, knows or should know that harm might occur if no warning is given.” Kokoyachuk, 172 Ill. App. 3d at 439. In the context of prescription drug litigation, this principle means that a drug manufacturer need not provide a warning of risks known to the medical community. See Wooten v. Johnson & Johnson Products, Inc., 635 F. Supp. 799 (N.D. Ill. 1986). Further, pharmaceutical warnings for prescription drugs are given to physicians as "learned intermediaries.” Northern Trust Co. v. Upjohn Co., 213 Ill. App. 3d 390, 572 N.E.2d 1030 (1991).
From the evidence it is clear that Upjohn knew or should have known that Depo-Medrol is an insoluble, toxic material which, *278because of its insolubility, when inserted in the eye, became a foreign body, and was very difficult, if not impossible, to remove. Upjohn, its manufacturer, must be held to the standard of an expert in the field (McEwen v. Ortho Pharmaceutical Corp., 270 Or. 375, 528 P.2d 522 (1974)) and had a "continuous duty *** to warn physicians of the dangers incident to prescribing the drug, to keep abreast of scientific developments touching upon the manufacturer’s product and to notify the medical profession of any additional side effects discovered from its use.” (Emphasis added.) Schenebeck v. Sterling Drug, Inc., 423 F.2d 919, 922 (8th Cir. 1970). If Upjohn did not know what it should have known, it failed in its duty as an expert. It could not fulfill that duty merely by waiting for what it considered sufficient proof of a cause-effect relationship before advising the medical profession with an appropriate alert or warning of the possibility of risk in the use of one of its products. See Mahr v. G.D. Searle & Co., 72 Ill. App. 3d 540, 564, 390 N.E.2d 1214 (1979) (Mahr). Nor can failure to do so be excused merely by the fact that the potentially endangered users are few in number. Mahr, 72 Ill. App. 3d at 560; Crocker v. Winthrop Laboratories, Division of Sterling Drug, Inc., 514 S.W.2d 429, 432 (Tex. 1974). The injury here clearly was within the scope of the dangerous propensities of the drug for which Upjohn must be held accountable. See McMahon v. Eli Lilly & Co., 774 F.2d 830, 835 (7th Cir. 1985).
The evidence revealed that Upjohn knew of Depo-Medrol’s dangerous propensities before the instant occurrence took place in 1983 (e.g., 291 Ill. App. 3d at 270-71 n.3); yet, there was no reference in the 1983 label or insert that subconjunctival use of Depo-Medrol as practiced upon Proctor in this case was not recommended by Upjohn, nor that FDA approval was never secured for such application. There was no mention on the label that one cubic centimeter (cc) amount of the drug for use about and around the eye was an excessive dosage, according to one of its own experts. E.g., 291 Ill. App. 3d at 271 n.3. Tissue atrophy developed in some patients after injection, which could be considered as evidence of a toxic effect, also known by Upjohn before 1983. E.g., 291 Ill. App. 3d at 271 n.3. The 1983 package insert made no reference to the fact, known by Upjohn, that the drug should be administered intramuscularly as " 'probably the predominant steroid effect is going to be a systemic effect anyway.’ ” E.g., 291 Ill. App. 3d at 271 n.3. Nor did it point out that this preparation was a suspension and not a solution, and that the crystalline material in the area of sensitive subconjunctival tissue could be the cause in itself for injury. E.g., 291 Ill. App. 3d at 271 n.3. Dr. Walson, Proctor’s expert, was of the opinion that, given Upjohn’s knowledge of the foregoing facts in 1962, the drug company should have warned *279that periocular use of the drug was not recommended, and under the adverse reaction section of the warning, should have listed the toxicity of the drug.
As previously noted, the FDA had approved the use of Depo-Medrol only for certain other uses, involving three specific means of administration: intramuscularly, intra-articularly, and intralesionally; none of those approved uses included the periocular use to which the drug was put in this case. Federal law required Upjohn to include package inserts and labeling recommendations which referred only to the three approved forms of administration for its product. Upjohn should have warned Dr. Davis and others of its potentially harmful effects about which Upjohn knew soon after it went on the market.
The record demonstrates that, by 1961, Upjohn had learned that some ophthalmologists were administering Depo-Medrol through periocular injection as an "off-label” use. Upjohn fostered and encouraged this unapproved use as experimentation on human beings with no prior basic scientific studies having been made. This unauthorized use, encouraged by Upjohn, became more widespread in the next two decades, although Upjohn never secured FDA approval for it and never set forth the use, warnings or directions for such periocular injections on its labels or in its literature. None of the dangers attendant to such use, or any reported deleterious side effects which may have developed of which Upjohn was apprised through DERs, were made known to the prescribing or treating physicians who made this unauthorized off-label use of it. Dr. Davis testified that he did not know of the drug’s dangerous propensities, or he would not have used it. Dr. Thomas Deutsch, Upjohn’s own expert, asserted that, until he testified in this case, he did not know Depo-Medrol would be difficult or impossible to remove once injected into the eye.
Under such circumstances, physicians could not be deemed "learned intermediaries” who were aware of these dangers of Depo-Medrol; they required warnings because the medical community in 1983 was not aware of the risk of serious injury, including vision loss. See Mahr, 72 Ill. App. 3d at 560. No physician or expert witness testified that the medical community knew what Upjohn knew with respect to dangérous toxicity and irremovability of this drug, but shared with no one except its own employees.11 There is no record evidence to support the hypothesis that the medical community knew of these *280dangerous propensities. See Tongate v. Wyeth Laboratories, 220 Ill. App. 3d 952, 963, 580 N.E.2d 1220 (1991) (Tongate). The record supports the jury’s determination in this regard.
A drug such as Depo-Medrol may be deemed unreasonably dangerous absent an adequate warning accompanying the product because the product may be "unavoidably unsafe” without such a warning. Kirk v. Michael Reese Hospital & Medical Center, 117 Ill. 2d 507, 517, 513 N.E.2d 387 (1987); Lawson v. G.D. Searle & Co., 64 Ill. 2d 543, 550-51, 356 N.E.2d 779 (1976). A manufacturer of ethical drugs cannot evade its responsibilities of warning physicians of dangers and risks attendant to the use of its products, by hoping, as in the present case, that the doctors will learn of the dangers themselves. Upjohn’s duty to warn was nondelegable; the failure of prescribing and treating physicians to learn of the risks of a drug from other sources does not relieve the manufacturer of liability for harm resulting from its own failure to adequately warn. Mahr, 72 Ill. App. 3d at 566. This point was explicated in Mahr, 72 Ill. App. 3d at 561-62.12 Here, Upjohn knew of the risks, yet did not share this knowledge with members of the profession acting in decision-making *281capacities in administering drugs to their patients, and encouraged unapproved use and misleading publicity.13 When doctors are properly warned of the possibility of side effects and advised of the symptoms accompanying them, the chances that injury to the patient can be avoided are enhanced, particularly if it takes place slowly, as in the case with the injury in question here. Sterling Drug, Inc. v. Cornish, 370 F.2d 82, 85 (8th Cir. 1966).
Significantly, Upjohn knew how to warn, and did warn doctors against certain uses of Depo-Medrol by advising them, for example, against intrathecal administration of this drug, which it printed on *282the insert distributed with the drug in 1983, before the instant insertion of Depo-Medrol into Proctor’s eye. Upjohn, in another line or two of print on the insert, easily could have mentioned potential adverse reactions to the drug when injected intraocularly, of which it had learned over a period of preceding years from the DERs. See 291 Ill. App. 3d at 274-75 n.9. Information regarding questionable reactions or side effects to this Upjohn product contained in DERs in Upjohn’s possession was not shared by it with the medical community by any other means.14 According to Dr. Walson, being on notice of that kind of information from the 1960s up to 1983, there were methodologies and scientific means available to Upjohn to confirm or disaffirm the toxicity of the drug. In his opinion, Upjohn should have included a warning on its label or package insert which said, in effect, do not use the drug in that way, and if so used, this is what may be seen.15 This was never done. In light of this imbalance of access to information about adverse propensities of Depo-Medrol, it cannot be *283concluded that physicians had knowledge of the risks equal to Upjohn’s.
The jury heard Upjohn’s Dr. Stubbs testify. He was in charge of Depo-Medrol development. He did not know about the pharma-kinetic effects of Depo-Medrol when used in a local injection rather than systemic. He did not know how difficult it would be to remove Depo-Medrol from the eye. He did not have anyone investigate by animal studies whether the drug would be toxic if it got into the eye. Prior to November 7, 1983, Dr. Stubbs never asked any Upjohn in-house personnel whether or not it would be difficult to remove the substance once it was injected into the eye.
A drug company cannot absolve itself from the duty to warn by pointing to the unauthorized use of its drug by physicians with whom it has not shared its knowledge of dangerous side effects and injury. Violation of its duty to warn is even more egregious in this case since, as the evidence heard by the jury demonstrated, Upjohn encouraged and participated in disseminating misleading information concerning the use of its drug to the "learned intermediaries,” through financial support, technical assistance, and abundant supplies of the drug during the period when Upjohn was receiving adverse information concerning this use of the drug. Ironically, some of these very reports became part of the literature that was supposed to inform the "learned intermediaries” about application of the drug intraocularly. Proctor’s expert testified that ophthalmologists were not aware of the true facts but believed that periocular use of Depo-Medrol was safe and efficacious. Significantly, in fact, Upjohn’s own expert, Dr. Thomas Deutsch, an ophthalmologist, testified he did not learn that periocular injections of Depo-Medrol were difficult or impossible to withdraw and were an unlabeled use until after he became an expert in this case. Doctors who have not been sufficiently warned of the harmful effects of a drug cannot be considered "learned intermediaries” and the adequacy of warnings is a question of fact, not law, for the jury to determine, as it did in the instant case. Tongate, 220 Ill. App. 3d at 963; Batteast v. Wyeth Laboratories, Inc., 137 Ill. 2d 175, 192-94, 560 N.E.2d 315 (1990).
The evidence convincingly supports the conclusion that Upjohn promoted, encouraged and advertised the off-label use of Depo-Medrol by providing financial and technical assistance to a limited number of members of the medical community without attempting to communicate to these physicians and the medical community at large *284the dangers and risks attendant to this use.16 Although it is assumed that physicians will keep abreast of current medical literature, here, part of the flawed literature was generated by Upjohn. Upjohn even sought to "plant the seed” in doctors’ minds about contributing to the literature, and thereby help to mislead the specialized ophthalmic community as to the potential harmful effects attendant to the intraocular injection of a drug which could be impossible to remove. To conclude that the existence of literature in such a case constitutes knowledge on the part of doctors and the medical community equal to that of a drug’s manufacturer would encourage more writings of the type found in this case, fostered by the very defendant upon whom responsibility should be fixed. Such an insidious situation as here existed should be neither countenanced, encouraged nor condoned. The evidence demonstrates that Upjohn knew or should have known of the risks and dangers attendant to the use of Depo-Medrol, thereby requiring warning. Woodill v. Parke Davis & Co., 79 Ill. 2d 26, 35, 402 N.E.2d 194 (1980). Upjohn simply failed to do so.
Upon this record, the jury had the right to conclude that Upjohn violated its duty to adequately warn and that it be held accountable under these circumstances. The evidence on this point, when "viewed in its aspect most favorable to [Proctor, does not] so overwhelmingly favor[ ] [Upjohn] that no contrary verdict based on that evidence could ever stand” (Pedrick, 37 Ill. 2d at 510), so as to have warranted judgment notwithstanding the verdict entered in this case. Nor was the grant of a new trial authorized under Maple, 151 Ill. 2d at 455, on this point since the jury’s verdict was well supported by the evi*285dence and Upjohn was not denied a fair trial. Upjohn’s contentions are rejected.17
II
Upjohn next contests the punitive damages judgment, asserting: (1) there was insufficient evidence to support liability for punitive damages; (2) a new trial must be awarded with respect to punitive damages; and (3) the punitive damages award is grossly excessive.
Illinois courts have long been concerned that punitive damages not be awarded improperly or unwisely. Cornell v. Langland, 109 Ill. App. 3d 472, 475, 440 N.E.2d 985 (1982). The purpose of punitive damages is not compensation of plaintiff, but punishment of defendant and deterrence; therefore, these damages can be awarded only for conduct that is outrageous either because defendant’s acts are done with an evil motive or a reckless indifference to others’ rights. Loitz v. Remington Arms Co., 138 Ill. 2d 404, 415-16, 563 N.E.2d 397 (1990), quoting Restatement (Second) of Torts § 908, Comment b, at 464-65 (1979).
Punitive damages are similar to criminal penalties (Deal v. Byford, 127 Ill. 2d 192, 203, 537 N.E.2d 267 (1989)) and are permissible only in cases in which torts "are committed with fraud, actual malice, deliberate violence or oppression, or when the defendant acts willfully, or with such gross negligence as to indicate a wanton disregard of the rights of others.” Kelsay v. Motorola, Inc., 74 Ill. 2d 172, 186, 384 N.E.2d 353 (1978). The initial decision whether punitive damages may be imposed in a particular case is a matter usually reserved to the circuit court (Loitz, 138 Ill. 2d at 415), and its decision will not be reversed absent an abuse of discretion. Levy v. Markal Sales Corp., 268 Ill. App. 3d 355, 379, 643 N.E.2d 1206 (1994). A reviewing court "may reverse the amount of punitive damages only where 'it is apparent that the award is the result of passion, partiality, or corruption.’ ” Levy, 268 Ill. App. 3d at 379, quoting Deal, 127 Ill. 2d at 204.
There was evidence presented here that Upjohn not only knew of the adverse effects of periocular use of Depo-Medrol, but promoted and developed this off-label use through financial and technical assistance to doctors. After those doctors wrote up their case reports with Upjohn’s assistance, Upjohn distributed them, thereby helping to create the literature touting the periocular use of Depo-Medrol. There *286was sufficient evidence of willful and wanton conduct to justify the imposition of punitive damages.
Upjohn’s contention that the jury instructions on punitive damages were inadequate is not persuasive. The jury was instructed that "willful and wanton conduct” means "a course of action which shows an utter indifference to or conscious disregard for the safety of others.”18 Given the status of Illinois law on punitive damages discussed above, we cannot say that the instructions do not state the law accurately. The circuit court did not abuse its discretion in giving these punitive damages instructions to the jury.
Upjohn also maintains the court erred in permitting argument concerning Upjohn’s net worth. Upjohn, however, cannot show the court abused its discretion in admitting evidence of its net worth. See E.J. McKernan Co. v. Gregory, 252 Ill. App. 3d 514, 536, 623 N.E.2d 981 (1993), quoting Deal, 127 Ill. 2d at 204-05. Upjohn has failed to demonstrate that the evidence was irrelevant and prejudicial with respect to either compensatory or punitive damages.
Upjohn’s most persuasive argument is that the punitive damages awarded are excessive and should be reduced.
In reviewing punitive damage awards, the question of excessiveness turns on whether the amount is so large that it outruns the justification for exacting punitive damages, namely, retribution and deterrence of future outrageous conduct. Marek v. Stepkowski, 241 Ill. App. 3d 862, 608 N.E.2d 285 (1992). A reviewing court considers the degree of reprehensibility of defendant’s conduct, the relationship between the punitive damage award and the harm caused by the conduct, defendant’s gain from the misconduct, and the financial condition of defendant. See Pacific Mutual Life Insurance Co. v. Haslip, 499 U.S. 1, 113 L. Ed. 2d 1, 111 S. Ct. 1032 (1991); Deal, 127 Ill. 2d at 203-04. This court’s inquiry is thus one of degree: when arrayed along the spectrum of wrongful acts, was the conduct at issue here so extraordinarily outrageous as to justify extraordinary punitive damages? The circuit court, in its review of the punitive damages awarded, answered that question in the affirmative, although it *287remitted the jury’s award by almost 75%. The original award of more than $124 million amounted to precisely 7% of Upjohn’s net worth; the remitted amount is still more than 2% of the company’s net worth and more than eleven times the amount of compensatory damages awarded.
When we consider the factors set out by the United States Supreme Court and Illinois courts, we find that the amount of punitive damages awarded in this case far outruns the justification for imposing punitive damages. We agree with the circuit court that Upjohn’s conduct was sufficiently reprehensible to support an award of punitive damages; however, there is no reasonable relationship between the amount of the punitive damages and the harm caused by the conduct. Further, although Upjohn is a large corporation with a net worth of approximately $1.7 billion, punishment in the amount of 2% of its net worth is excessive in the extreme.
Illinois courts have recognized that the level of compensatory damages may be an appropriate measure of punitive damages. See Brown v. Farkas, 158 Ill. App. 3d 772, 780, 511 N.E.2d 1143 (1986). It is important, however, not to belittle the meaning of the jury’s decision and the determination of the circuit court that a $35 million award was proper given Upjohn’s willful and wanton conduct. We believe that a punitive damage award twice that of the compensatory damage award will send a strong message to pharmaceutical manufacturers of the necessity to warn of the known potential adverse effects of their drugs. The twin goals of retribution and deterrence would both be met by such an award. Pursuant to Supreme Court Rule 366, we enter a remittitur of the punitive damages to $6,095,639.52. 134 Ill. 2d R. 366.
For the foregoing reasons the judgment of the circuit court is affirmed in part; vacated in part; and remittitur is entered as noted above.
Affirmed in part; vacated in part; and remittitur entered.
TULLY, J., concurs.